Mr. Otto Schwarz has been Advisor of Actelion Ltd since June 16, 2017. Mr. Schwarz served as the Chief Operating Officer and Executive Vice President at Actelion Ltd from June 7, 2011 to June 16, 2017. He has been the President of Business Operations of Actelion Pharmaceuticals U.S. Inc. since 2008. Mr. Schwarz served as President of Business Strategy and Operations of Actelion Ltd. from January 14, 2008 to June 7, 2011. He served as an Executive Vice President of Commercial Operations at Nycomed SICAR S.C.A. until September 10, 2007 and served as its Member of Executive Board, Business Strategy & Commercial Operations. Mr. Schwarz served as an Executive Vice President, Commercial Operations of Takeda Pharmaceuticals International GmbH (also known as Nycomed International Management GmbH). Mr. Schwarz served as Business Strategy and Commercial Operations Head at Nycomed GmbH. He is a Member of the Board of Management at Nycomed GmbH since 2004. He held Various manage¬rial positions at Schering Plough incl., as Senior Vice President of Schering-Plough Mid-Europe; Marketing Planning Manager at Eli Lilly. He held Managerial Positions at Novo S.A. in Austria. Mr. Schwarz has more than 20 years in the pharmaceutical industry. He is a qualified pharmacist and has a PhD in Pharmaceutical Chemistry from the University of Vienna Austria and postdoc at the University of Florida, Gainesville, US.